Harrison Ford, who appeared in the three earlier flicks, the last one coming in 1989, is set to star again.
Lucas said he and Steven Spielberg recently finalized the script for the film.
"It's going to be fantastic. It's going to be the best one yet," the 62-year-old filmmaker said during a break from preparing for his duties as grand marshal of Monday's Rose Parade.
Exact film locations have not been decided yet, but Lucas said part of the movie will be shot in Los Angeles.
"George, Harrison and I are all very excited," Spielberg said, according to The Hollywood Reporter. "We feel that the script was well worth the wait. We hope it delivers everything you'd expect from our history with Indiana Jones."
In a statement, the 64-year-old Ford said he was ready for another turn as the globe-trotting archaeologist. "I'm delighted to be back in business with my old friends," he said. "I don't know if the pants still fit, but I know the hat will."
The fourth chapter of the "Indiana Jones" saga, which will hit theaters in May 2008, has been in development for over a decade with several screenwriters taking a crack at the script, but it only recently gained momentum. According to The Hollywood Reporter, the script that met the three principals' approval is by David Koepp ("Jurassic Park," "War of the Worlds," "Spider-Man").
Lucas kept mum about the plot, but said that the latest action flick will be a "character piece" that will include "very interesting mysteries."
"I think it's going to be really cool," Lucas said.
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